Concern about liver disease in children / 中华肝脏病杂志

With the economic development and living standards improvement, various chronic viral liver diseases in children is decreasing year by year, and the liver diseases related to heredity, environment and living habits is increasing. Although liver disease in children is relatively rare and is not the main cause of childhood mortality, chronic liver disease cannot be ignored for its effect on children's growth and development, mental health, quality of life and the economic burden to family or society. Therefore, more attention should be paid to the early screening, diagnosis and treatment of pediatric liver diseases, in order to delay or prevent its progression efficiently.

Inherited metabolic diseases and liver transplantation / 中华肝脏病杂志

Worldwide, liver transplantation for adults and children is rapidly developing with the advancement of surgical techniques, market availability of new immunosuppressant drugs, and improved post-surgical management. Previously, liver transplantation was limited to end-stage liver disease, but recently many patients with inherited metabolic diseases achieves prolong survival and better quality of life. This article reviews the latest trends in the relationship between inherited metabolic diseases and liver, characteristics of inherited metabolic liver diseases, inherited metabolic disorders that may need liver transplantation, indications for liver transplant, and the key points of perioperative management.

Focus on diagnosis and treatment of genetic liver disorders / 中华肝脏病杂志

The advancement and popularization of molecular diagnostic techniques has challenged and redefined the traditional concept of genetic metabolic disease. Regardless of disease origin, all genetic defects that lead to hepatobiliary dysfunction or structural abnormalities are termed as genetic liver disorders. Online Mendelian Inheritance in Man (OMIM) is a database consisting 693 genetic diseases with clear molecular mechanism of liver related phenotypes. Moreover, the effective measures to control infectious liver disease have strengthened the importance of research in the field of (adult and children) genetic liver disorders at home and abroad by well-recognized hepatologists. Notably, all patients with unexplained hepatopathy and multiple system diseases involving liver and gallbladder needs screening for genetic liver disorders, except for factors such as infection, immunity, drug-related, and anatomical abnormalities. We hope more patients with complicated liver disorders will benefit from definitive diagnosis and effective treatment in the near future with clear explanation of clinical phenotype, genotype, and metabolomics.

Focus on diagnosis and treatment of genetic liver disorders / 中华肝脏病杂志

The advancement and popularization of molecular diagnostic techniques has challenged and redefined the traditional concept of genetic metabolic disease. Regardless of disease origin, all genetic defects that lead to hepatobiliary dysfunction or structural abnormalities are termed as genetic liver disorders. Online Mendelian Inheritance in Man (OMIM) is a database consisting 693 genetic diseases with clear molecular mechanism of liver related phenotypes. Moreover, the effective measures to control infectious liver disease have strengthened the importance of research in the field of (adult and children) genetic liver disorders at home and abroad by well-recognized hepatologists. Notably, all patients with unexplained hepatopathy and multiple system diseases involving liver and gallbladder needs screening for genetic liver disorders, except for factors such as infection, immunity, drug-related, and anatomical abnormalities. We hope more patients with complicated liver disorders will benefit from definitive diagnosis and effective treatment in the near future with clear explanation of clinical phenotype, genotype, and metabolomics.

Training enhancement for new challenges in pediatric liver diseases / 临床肝胆病杂志

With the improvement in health economics and wide application of vaccines, the incidence of viral hepatitis decreases dramatically; however, the proportion of non-infectious liver diseases, such as nonalcoholic fatty liver disease, hereditary liver disease, and autoimmune hepatitis, climbs up rapidly. This paper summarizes the development and current situation of the subspecialties of pediatric liver diseases. In recent years, the clinical and basic research on domestic pediatric liver diseases has made some progress through the application of new techniques, such as liver biopsy, bile acid spectrum analysis, screening for inherited metabolic diseases, and genetic diagnosis. However, Chinese pediatricians are confronting new challenges from growing knowledge on liver diseases, expanding disease spectrum, and increasing demand for liver transplant. However, there is an urgent need to enhance the development of the subspecialty of pediatric hepatology in China, because most Chinese pediatricians have little knowledge of liver diseases, and there is a severe shortage of specialized medical staff for pediatric liver diseases.